Casp8-Flox

系統名

C57BL/6Smoc-Casp8em1(flox)Smoc

SMOC番号

NM-CKO-190003

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Casp8

Synonyms

MACH， Mch5， FLICE， CASP-8

NCBI ID

12370

MGI ID

1261423

Ensembl ID

ENSMUSG00000026029

Pubmed

Casp8

Human Ortholog

CASP8

説明

These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
応用分野：cancer research,Apoptosis

病気の予測

Autoimmune Lymphoproliferative Syndrome Type 2B

表現型

MGI:2655731
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lck-cre mice.

参考文献

Salmena L, Hakem R, Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med. 2005 Sep 19;202(6):727-32

Atopic Dermatitis

表現型

MGI:4888399
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with KRT14-cre mice.

参考文献

Li C, Lasse S, Lee P, Nakasaki M, Chen SW, Yamasaki K, Gallo RL, Jamora C, Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22249-54

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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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