Fas-KO(BALB/c)

系統名

BALB/cAnSmoc-Fasem2Smoc

SMOC番号

NM-KO-191206

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Fas

Synonyms

lpr， APO1， APT1， CD95， TNFR6， Tnfrsf6， AI196731

NCBI ID

14102

MGI ID

95484

Ensembl ID

ENSMUSG00000024778

Pubmed

Fas

Human Ortholog

FAS

説明

Exon 2 of Fas gene was deleted to generate Fas knockout mice.
応用分野：Immune-related

病気の予測

Systemic Lupus Erythematosus

表現型

MGI:3800222
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tnfrsf9-KO(2)(NM-KO-210216) mice.

参考文献

Ohta A, Sekimoto M, Sato M, Koda T, Nishimura S, Iwakura Y, Sekikawa K, Nishimura T, Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol. 2000 Jul 15;165(2):956-61

Systemic Lupus Erythematosus

表現型

MGI:5478500
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tlr9-KO(NM-KO-190168) mice.

参考文献

Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ, Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006 Sep;25(3):417-28

Membranous Glomerulonephritis

表現型

MGI:4943704
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Il27ra-KO(NM-KO-190496) mice.

参考文献

Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, Akahoshi M, Katafuchi R, Hirakata H, Harada M, Hamano S, Nakashima H, Yoshida H, Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005 Dec 1;175(11):7185-92

Systemic Lupus Erythematosus

表現型

MGI:3665495
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ccr2-KO(NM-KO-190018) mice.

参考文献

de Lema GP, Maier H, Franz TJ, Escribese M, Chilla S, Segerer S, Camarasa N, Schmid H, Banas B, Kalaydjiev S, Busch DH, Pfeffer K, Mampaso F, Schlondorff D, Luckow B, Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. J Am Soc Nephrol. 2005 Dec;16(12):3592-601

Autoimmune Lymphoproliferative Syndrome

表現型

MGI:2450098

参考文献

Adachi M, SuematsuS, Suda T, Watanabe D, FukuyamaH, Ogasawara J, Tanaka T, Yoshida N, Nagata S, Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6

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