Zap70-W163C(Balb/c)

系統名

BALB/cAnSmoc-Zap70em(W163C)Smoc

SMOC番号

NM-KI-210366

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol
Zap70

Synonyms

Srk; mur; mrtle; ZAP-70

NCBI ID

22637

MGI ID

99613

Ensembl ID

ENSMUSG00000026117

Pubmed

Zap70

Human Ortholog

ZAP70

説明

These mice carry a W163C mutation of Zap70 gene.

応用分野：Rheumatoid arthritis model， Ankylosing spondylit，SKG mouse arthritis modelis model

病気の予測

Rheumatoid Arthritis

表現型

MGI:3698734

参考文献

Sakaguchi N, Takahashi T, Hata H, Nomura T, Tagami T, Yamazaki S, Sakihama T, Matsutani T, Negishi I, Nakatsuru S, Sakaguchi S, Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60

表現型データ

image.png

Fig.1 Clinical score of joint swelling in HO Zap70-W163C (Balb/C) mice(A) and representative diagram of hind limb joints of mice in each group on day 52(B) (female, 6-8wks). Compared with the control group, the mannan-induced mice gradually increased their joint swelling scores over time.

Signs of arthritis were assessed by a visual score where 0= Normal paw, 1 = one toe inflamed or swollen, 2 = more than one toe, but not entire paw, or mild swelling of the entire paw, 3 = entire paw inflamed and swollen, and 4 = very inflamed and swollen paw or ankylosed paw.

image.png

Fig.2 Hindlimb micro-CT image of HO Zap70-W163C(Balb/C) mice in  the control (G1) and model groups (G2) (female, 6-8wks). The orange arrows point to osteophytes.

image.png

Fig.3 Score of HO Zap70-W163C(Balb/C) mice (A) and H&E pathology(B). (female, 6-8wks, n=3)

Compared with G1, the infiltration of mixed inflammatory cells in the induced group was significantly increased, and the synovial membrane of the joints showed obvious hyperplasia, pannu formation, fibrous tissue formation, and cartilage erosion.

出版物

A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation
References：Journal of Nanobiotechnology

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細