Bag3-Flox

系統名

C57BL/6Smoc-Bag3em1(flox)Smoc

SMOC番号

NM-CKO-2101856

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Bag3

Synonyms

Bis， mg638， AA407278

NCBI ID

29810

MGI ID

1352493

Ensembl ID

ENSMUSG00000030847

Pubmed

Bag3

Human Ortholog

BAG3

説明

These mice carry loxP sites flanking exon 4 of Bag3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bag3 gene.

病気の予測

Dilated Cardiomyopathy 1Hh

表現型

MGI:6107901
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myhca-cre mice.

参考文献

Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J, Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01;127(8):3189-3200

dilated cardiomyopathy 1HH

表現型

MGI:6107910
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myhca-cre mice.

参考文献

Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J, Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01;127(8):3189-3200

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