Myocd-Flox

系統名

C57BL/6Smoc-Myocdem1(flox)Smoc

SMOC番号

TBD

維持形態

Developing

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遺伝子の概要

Gene Symbol
Myocd

Synonyms

Srfcp， BSAC2A

NCBI ID

214384

MGI ID

2137495

Ensembl ID

ENSMUSG00000020542

Pubmed

Myocd

Human Ortholog

MYOCD

説明

These mice carry loxP sites flanking target exons of Myocd gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Myocd gene.

病気の予測

Patent Ductus Arteriosus

表現型

MGI:3797716
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pax3-cre mice.

参考文献

Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS, Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008 Feb;118(2):515-25

Dilated Cardiomyopathy

表現型

MGI:5907042
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.

参考文献

Huang J, Min Lu M, Cheng L, Yuan LJ, Zhu X, Stout AL, Chen M, Li J, Parmacek MS, Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18734-9

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