Ldlr-KO(2)

系統名

C57BL/6Smoc-Ldlrem1Smoc

SMOC番号

NM-KO-210198

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Ldlr

Synonyms

Hlb301

NCBI ID

16835

MGI ID

96765

Ensembl ID

ENSMUSG00000032193

Pubmed

Ldlr

Human Ortholog

LDLR

説明

Ldlr-KO(2) mice(Stock No.NM-KO-210198) carry a knockout allele derived from the targeted deletion of exon 4. While Ldlr-KO mice(Stock No.NM-KO-190559) carrying the exon 6-10 deletion.

病気の予測

familial hypercholesterolemia

表現型

MGI:3691620

参考文献

Jones C, Hammer RE, Li WP, Cohen JC, Hobbs HH, Herz J, Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem. 2003 Aug 1;278(31):29024-30

Fatty Liver Disease

表現型

MGI:3611043

参考文献

Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, Haigh WG, Yeh MM, Kowdley KV, O'Brien KD, Pennathur S, Chait A, Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res. 2011 Sep;52(9):1626-35

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