Hnf4a-Flox

系統名

C57BL/6Smoc-Hnf4atm1(flox)Smoc

SMOC番号

NM-CKO-190062

維持形態

Sperm cryopreservation

PDFを取得

遺伝子の概要

Gene Symbol
Hnf4a

Synonyms

Hnf4; HNF-4; MODY1; Nr2a1; Tcf14; TCF-14; Hnf4alpha

NCBI ID

15378

MGI ID

109128

Ensembl ID

ENSMUSG00000017950

Pubmed

Hnf4a

Human Ortholog

HNF4A

説明

These Hnf4a flox mice possess loxP sites flanking exon 2. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
応用分野：Transcriptional regulator, insulin secretion related

病気の予測

Fanconi Syndrome

表現型

MGI:6392256
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Six2-cre mice.

参考文献

Marable SS, Chung E, Adam M, Potter SS, Park JS, Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome. JCI Insight. 2018 Jul 25;3(14)

Maturity-Onset Diabetes Of The Young Type 1

表現型

MGI:3653173
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ins2-cre mice.

参考文献

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I, Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J Biol Chem. 2006 Feb 24;281(8):5246-57

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

詳細