Cav1-KO

系統名

C57BL/6Smoc-Cav1em1Smoc

SMOC番号

NM-KO-190930

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Cav1

Synonyms

Cav; Cav-1

NCBI ID

12389

MGI ID

102709

Ensembl ID

ENSMUSG00000007655

Pubmed

Cav1

Human Ortholog

CAV1

説明

Exon 3 of Cav1 gene was deleted to generate Cav1 knockout mice.
応用分野：Tumor suppression,vascular system,fibrosis,Berardinelli-Seip congenital lipodystrophy

病気の予測

Alzheimer's Disease

表現型

MGI:5014041

参考文献

Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH, Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010;5(12):e15697

Breast Cancer

表現型

MGI:3843497

参考文献

Mercier I, Casimiro MC, Zhou J, Wang C, Plymire C, Bryant KG, Daumer KM, Sotgia F, Bonuccelli G, Witkiewicz AK, Lin J, Tran TH, Milliman J, Frank PG, Jasmin JF, Rui H, Pestell RG, Lisanti MP, Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol. 2009 Apr;174(4):1172-90

Hypertrophic Cardiomyopathy

表現型

MGI:2669401

参考文献

Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP, Caveolin-1 Null (-/-) Mice Show Dramatic Reductions in Life Span. Biochemistry. 2003 Dec 30;42(51):15124-15131

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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