Cdk4-KO
系統名
C57BL/6Smoc-Cdk4em1Smoc
SMOC番号
NM-KO-190614
維持形態
Developing
遺伝子の概要
Gene Symbol
Cdk4
説明
Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.
応用分野：The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).
*Literature published using this strain should indicate: Cdk4-KO mice (Cat. NO. NM-KO-190614) were purchased from Shanghai Model Organisms Center, Inc..
病気の予測
Type 1 Diabetes Mellitus
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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