Stat3-Flox

系統名

C57BL/6Smoc-Stat3tm7(flox)Smoc

SMOC番号

NM-CKO-200050

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Stat3

Synonyms

Aprf; AW109958; 1110034C02Rik

NCBI ID

20848

MGI ID

103038

Ensembl ID

ENSMUSG00000004040

Pubmed

Stat3

Human Ortholog

STAT3

説明

These mice carry loxP sites flanking exon 12-14 of Stat3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stat3 gene.While Stat3-Flox(2)(Stock No.NM-CKO-200225）mice carrying the loxP sites flanking exon 18-20 of Stat3 gene.
応用分野：Cancer research

病気の予測

Inflammatory Bowel Disease

表現型

MGI:2683230
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.

参考文献

Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY, Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med. 2003 Nov 17;198(10):1517-25

inflammatory bowel disease

表現型

MGI:3783296
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tek-cre mice.

参考文献

Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY, STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84

Peripartum Cardiomyopathy

表現型

MGI:5906908
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Myh6-cre mice.

参考文献

Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H, A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell. 2007 Feb 9;128(3):589-600

Inflammatory Bowel Disease

表現型

MGI:4429499
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Csf1r-icre mice.

参考文献

Deng L, Zhou JF, Sellers RS, Li JF, Nguyen AV, Wang Y, Orlofsky A, Liu Q, Hume DA, Pollard JW, Augenlicht L, Lin EY, A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol. 2010 Feb;176(2):952-67

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