Ar-Flox

系統名

B6;129S-Artm1(flox)Smoc

SMOC番号

NM-CKO-00110

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Ar

Synonyms

Tfm; AW320017

NCBI ID

11835

MGI ID

88064

Ensembl ID

ENSMUSG00000046532

Pubmed

Ar

Human Ortholog

AR

説明

These mice carry loxP sites flanking exon 2 of Ar gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ar gene.

病気の予測

Prostate Cancer

表現型

MGI:5009703
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Pbsn-cre mice.

参考文献

Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H, Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer Cell. 2011 Jun 14;19(6):792-804

Type 2 Diabetes Mellitus

表現型

MGI:5502687
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fabp4-cre mice.

参考文献

McInnes KJ, Smith LB, Hunger NI, Saunders PT, Andrew R, Walker BR, Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis. Diabetes. 2012 May;61(5):1072-81

Obesity

表現型

MGI:2681522
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with CMV-cre mice.

参考文献

Matsumoto T, Takeyama K, Sato T, Kato S, Androgen receptor functions from reverse genetic models. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):95-9

出版物

Reproductive Deficits Induced by Prenatal Antimüllerian Hormone Exposure Require Androgen Receptor in Kisspeptin Cells
References：

Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils
References：Cell Reports

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