Ifng-Venus-Luc
系統名
C57BL/6Smoc-Ifngem1(IRES-Venus-Luci)Smoc
SMOC番号
NM-KI-18041
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
Ifng
説明
表現型データ
Fig1.MC38-OVA tumor volumes in Ifng-Venus-Luci reporter mice treated or not with anti-PD-1 mAb. Arrows indicate treatment days.
Fig2. In vivo imaging validation of MC38-OVA tumors in Ifng-Venus-Luci reporter mice treated or not with anti-PD-1 mAb.
In PBS treated control tumor, the IFNγ signal increased as the tumor growing. In anti-PD1 treated tumor, increased average BLI (Bioluminescent imaging) of IFNγ was shown 48h post the first dose compared to control group; as the tumor regression upon PD1 treatment, the IFNγ signal in tumor decreased as well.
The data is provided by Crownbio.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
詳細Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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