Il1b-Luc-2A-EGFP

系統名

C57BL/6Smoc-Il1bem1(Luc-eGFP)Smoc

SMOC番号

NM-KI-00010

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol
IL1B

Synonyms

Il-1b; IL-1beta

NCBI ID

16176

MGI ID

96543

Ensembl ID

ENSMUSG00000027398

Pubmed

IL1B

Human Ortholog

IL1B

説明

A Luciferase-2A-EGFP-pA cassette was inserted at ATG site of mouse Il1b gene. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il1b.
応用分野：Inflammation and immunity,gene tracing

表現型データ

微信截图_20211122150850.png

IL1B-2.png

Fig1. IL1β reporter gene expression in the mice was monitored through noninvasive molecular imaging. IL1 β  in the mouse body was activated through LPS  treatment.

2.png

Fig2. Analysis of EGFP expresssion in PBMC by FACS. The homozygous KI mouse expresses EGFP in  F4/80+ macrophages in peripheral blood.

3.png

Fig3. Analysis of EGFP expresssion in the spleen by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the spleen.

4.png

Fig4. Analysis of EGFP expresssion in the liver by FACS. The homozygous KI mouse expresses EGFP in F4/80+ macrophages in the liver.


出版物

Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice
References：ELSEVIER

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細