hAPOE4
系統名
C57BL/6JSmo-Apoetm2(hAPOE4)Smoc
SMOC番号
NM-HU-190002
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Apoe
説明
表現型データ
Fig1. Genotyping of WT 、KO & Humanized mice by PCR.
Primer P1/2 Wild type = 342 bp
Primer P3/4 mutant = 332 bp
M：100bp Plus DNA ladder.
Fig2. Detection of human APOE4 expression in Cerebellum in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig3. Detection of human APOE4 expression in Cornu ammonis 1(CA1) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig4. Detection of human APOE4 expression in Cornu ammonis 3(CA3) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig5. Detection of human APOE4 expression in Dentate Gyrus(DG) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig6. Blood biochemical analysis of hAPOE4 mice (female, n=3).
Fig7. Detection of Aβ Expression in Brain Tissues of hAPOE Mice.
No specific Aβ(6E10)-positive signals were detected. As illustrated in representative images of cortex and hippocampus, 4x
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