Gja1-2A-DreERT2

系統名

C57BL/6Smoc-Gja1em1(2A-DreERT2）Smoc

SMOC番号

NM-KI-200026

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Gja1

Synonyms

Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43

NCBI ID

14609

MGI ID

95713

Ensembl ID

ENSMUSG00000050953

Pubmed

Gja1

Human Ortholog

GJA1

説明

A 2A-DreERT2 expression cassette was knocked into the Gja1 gene stop codon site via CRISPR/Cas9 mediated recombination.
応用分野：Dre recombinase tool

表現型データ

image.png

Fig.1 DreERT2-mediated recombination in the adipose tissue of Gja1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the adipose tissue after tamoxifen treatment. Connexin 43 (Cx43, encoded by Gja1, green) is a cell-cell communication gap junction protein expressed in adipose tissue. (Documented in the following reference.)


出版物

A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting
References：CELL STEM CELL

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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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