Oxt-IRES-Cre

系統名

C57BL/6Smoc-Oxtem1(IRES-iCre)Smoc

SMOC番号

NM-KI-200090

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Oxt

Synonyms

OT; Oxy

NCBI ID

18429

MGI ID

97453

Ensembl ID

ENSMUSG00000027301

Pubmed

Oxt

Human Ortholog

OXT

説明

A IRES-iCre expression cassette was knocked into the Oxt gene stop codon site.
応用分野：Cre recombinase tool; Oxt-IRES-Cre mice express Cre recombinase under the control of the endogenous oxytocin (Oxt) promoter. Cre recombinase is expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in neurons expressing oxytocin.

表現型データ

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Fig. 1 Cre-mediated recombination in the brain of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the olfactory bulb, cortex, thalamus and cerebellum derived from OxtCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the eyes of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal inner nuclear layer and ganglion cell layer derived from OxtCre/+; Rosa26tdTomato/+ mouse. 

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Fig. 3 Detection of tdTomato(red) in various tissues of OxtCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, retina, pituitary gland, heart, lung, liver, salivary gland, brown fat, kidney, pancreas, intestine, colon, spleen, ovary, skeletal muscle, skin and thymus. (For more detailed information please contact our technical advisor.)


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