Pax7-IRES-CreERT2

系統名

C57BL/6Smoc-Pax7em1(IRES-Cre-ERT2)Smoc

SMOC番号

NM-KI-200099

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Pax7

Synonyms

Pax-7

NCBI ID

18509

MGI ID

97491

Ensembl ID

ENSMUSG00000028736

Pubmed

Pax7

Human Ortholog

PAX7

説明

A IRES-Cre-ERT2 expression cassette was knocked into the Pax7 gene stop codon site. Pax7 is expressed in myogenic progenitor cells. Pax7 is essential for the myogenic potential, survival, and proliferation of myogenic progenitors. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Pax7 after tamoxifen treatment.
応用分野：Cre recombinase tool

表現型データ

image.png

Fig. 1 CreERT2-mediated recombination in the muscle of Pax7CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle satellite cells of Pax7CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. Some leakiness were detected prior to tamoxifen exposure.

image.png

Fig. 2 Detection of tdTomato(red) in various tissues of Pax7CreERT2/+; Rosa26tdTomato/+ mice. Tdtomato can not be detected in the brain, colon, eye, heart, intestine, kidney, lung, liver, pancreas, stomach, spleen, skin, salivary gland, testis or epididymis. (For more detailed information please contact our technical advisor.)


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