hFcRn(SD)
系統名
SD-Fcgrtem1(hFCGRT)Smoc
SMOC番号
NR-HU-200002
維持形態
Repository Live
遺伝子の概要
説明
表現型データ
Fig1. Expression characterization of hFCRN in hFCRN knockin rat by Western blot.
Abbr. HO, homozygous; WT, wild type.
Fig2. PK study of Keytruda in hFCRN rat.
Fig3. PK study of Cyramza in hFCRN rat.
Fig.4 Blood concentration curve of test articles in hFcRn/hALB dKI rats (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001).
In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party)
Fig.5 PK study of Keytruda in hALB/hFCRN dKl rat (NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group)
Fig.6 PK study of Cyramza in hALB/hFCRN dKI rat(NR-HU-233317), which were generated by crossing hFCRN(SD)(NR-HU-200002) with hALB(SD)(NR-HU-200001). (n=3/time point/group)
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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