hTNFR2
系統名
C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Smoc
SMOC番号
NM-HU-190010
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
TNFRSF1B
説明
表現型データ
Validation of humanized TNFRSF1B(TNFR2) expression in the immune cells from Spleen
Fig1 The expression of human TNFRSF1B in humanized TNFRSF1B mice was measured by FACS. In humanized TNFRSF1B mice, active expression of human TNFRSF1B was detected in Treg cells and Neutrophils isolated from spleen. （In collaboration with CrownBio）
Validation of humanized TNFRSF1B(TNFR2) expression in the immune cells from Peripheral Blood
Fig2 The expression of human TNFRSF1B in humanized TNFRSF1B mice was measured by FACS. In humanized TNFRSF1B mice, active expression of human TNFRSF1B was detected in Treg cells and Neutrophils isolated from peripheral blood cells. （In collaboration with CrownBio）
Validation of humanized TNFRSF1B(TNFR2) expression in the immune cells from Lymph node
Fig3 The expression of human TNFRSF1B in humanized TNFRSF1B mice was measured by FACS. In heterozygous humanized TNFRSF1B mice, active expression of human TNFRSF1B was detected in Treg cells isolated from Lymph node. （In collaboration with CrownBio）
Fig 4. In vivo anti-tumor effect of anti-TNFRSF1B antibody, in a humanized mouse model of TNFRSF1B In vivo validation of anti-tumor efficacy in a MC38-OVA tumor-bearing model of humanized TNFRSF1B mice. Homozygous humanized TNFRSF1B mice were inoculated with MC38 colon cancer cells. The drug targeting human TNFRSF1B, showed a very significant anti-tumor effect, demonstrating that the humanized TNFRSF1B mice are a good in vivo model for validating the efficacy of antibodies targeting human TNFRSF1B.（In collaboration with CrownBio）
Fig5 FACS for blood upon TNFRSF1B antagonist treatment. Addition of antagonistic hTNFRSF1B antibody can impair hTNF-induced Treg cells proliferation, while the agonistic hTNFRSF1B antibody alone can induce a modest proliferative response.（In collaboration with CrownBio）
Fig6 TIL analysis upon TNFR2 antagonist treatment.
1 tumor in hTNFR2 Ab1 treatment group decreased (1/7, TV=0)
2 tumors in hTNFR2 Ab2 treatment group decreased (2/7, TV=0; 3/7 died during dosing period)
（In collaboration with CrownBio）
Fig7 TNFRSF1B blockade increases the Teff/Treg ratios in tumor microenvironment. （In collaboration with CrownBio）
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