hCD19/hCD3E

系統名

C57BL/6Smoc-Cd19em1(hCD19)Cd3eem1(hCD3E)/Smoc

SMOC番号

NM-HU-190027

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CD19

Synonyms

AW495831

NCBI ID

12478

MGI ID

88319

Ensembl ID

ENSMUSG00000030724

Pubmed

CD19

Human Ortholog

CD19

Gene Symbol
CD3E

Synonyms

CD3; T3e; AI504783; CD3epsilon

NCBI ID

12501

MGI ID

88332

Ensembl ID

ENSMUSG00000032093

Pubmed

CD3E

Human Ortholog

CD3E

説明

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.
応用分野：Immune-related

表現型データ

image.png

Fig1. Detection of CD19 expression in spleen by RT-PCR. Wild type: only one band at 368 bp with primers F1/R1(mCd19);Homoygous: only one band at 334 bp with primers F2/R2(hCD19); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Detection of CD3E expression in spleen by RT-PCR. Wild type: only one band at 465 bp with primers F1/R1(mCd3e);Homoygous: one band at 516 bp with primers F1/R1(recombinant hCD3E) and one band at 349 bp with primers F2/R2(hCD3E); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig3. Immunotype in blood in hCD19/hCD3E mice 

image.png

Fig4. Immunotype in blood in hCD19/hCD3E mice 

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Fig5. Immunotype in spleen in hCD19/hCD3E mice 

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Fig6. Immunotype in bone marrow in hCD19/hCD3E mice 

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