hC1S

系統名

C57BL/6Smoc-C1s1em1(hC1S)/Smoc

SMOC番号

NM-HU-2000077

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
C1s1

Synonyms

C1s; C1sa; AA959438; AI255193; AI327365

NCBI ID

50908

MGI ID

1355312

Ensembl ID

ENSMUSG00000038521

Pubmed

C1s1

Human Ortholog

C1S1

説明

The endogenous mouse C1s1 gene was replaced by human C1S gene.
応用分野：Immunotherapy,drug screening

表現型データ

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Fig1. Detection of C1S1 expression in bladder by RT-PCR. Wild type: only one band at 396 bp with primers F1/R1(mC1s1); Homozygous: only one band at 294 bp with primers F2/R2(hC1S1); Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of hC1S1 expression in serum by ELISA (n=8). Abbr. HO, homozygous; WT, wild type.

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Fig3. Detection of mC3 and mC5 expression in serum hC1S1 mice by ELISA (n=3). Abbr. HO, homozygous; WT, wild type.

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Fig .4 Detection of classical complement pathway activity in hC1S mice by ELISA. 

Abbr. HO, homozygous; WT, wild type; PC, Postive Control; NC, Negative Control. Unpaired t test were used, n.s. p>0.05.

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