hPD-L1/hCTLA-4

系統名

C57BL/6Smoc-Ctla4em1(hCTLA4)Cd274em1(hPD-L1)Smoc

SMOC番号

NM-HU-00102

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CTLA4

Synonyms

Cd152; Ly-56; Ctla-4

NCBI ID

12477

MGI ID

88556

Ensembl ID

ENSMUSG00000026011

Pubmed

CTLA4

Human Ortholog

CTLA4

Gene Symbol
Cd274

Synonyms

B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

NCBI ID

60533

MGI ID

1926446

Ensembl ID

ENSMUSG00000016496

Pubmed

Cd274

Human Ortholog

CD274

説明

hPD-L1(NM-HU-00062) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice
応用分野：Immunotherapy,cancer research,drug screening

表現型データ

PD-L1&CTLA4-HU.png


Fig1 Splenocytes from homozygous hPDL1/hCTLA4 mice were analyzed by flow cytometry after activation. mPDL1+ and mCTLA4+ were detectable in wild type (WT) C57BL/6, while hPDL1+ and hCTLA4+ cells were detectable in the homozygous hCTLA4/h4-1BB mice. 

ctla4-pdl1.png

ctla4-pdl1-2.png

Fig2  hCTLA-4/PD-L1 mice+ MC38 cells efficacy studies. We have developed a CTLA-4/PD-L1 dKI humanized model and tested the combined treatment of Yervoy and Tecentriq, and then observed improved efficacy in the combination treatment. 

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