hCD3EDG

系統名

C57BL/6-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/CbSmoc

SMOC番号

NM-HU-220120

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
CD3E

Synonyms

CD3; T3e; AI504783; CD3epsilon

NCBI ID

12501

MGI ID

88332

Ensembl ID

ENSMUSG00000032093

Pubmed

CD3E

Human Ortholog

CD3E

Gene Symbol
CD3D

Synonyms

T3d

NCBI ID

12500

MGI ID

88331

Ensembl ID

ENSMUSG00000032094

Pubmed

CD3D

Human Ortholog

CD3D

Gene Symbol
CD3G

Synonyms

T3g; Ctg3; Ctg-3

NCBI ID

12502

MGI ID

88333

Ensembl ID

ENSMUSG00000002033

Pubmed

CD3G

Human Ortholog

CD3G

説明

The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.

表現型データ

image.png

Fig 1. Expression detection of human CD3E/CD3D/CD3G by FACS in homozygous hCD3EDG mice.

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Fig 2. Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody in parallel with homozygous hCD3EDG mice.

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Fig 3. Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.

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