hSIGLEC15

系統名

C57BL/6Smoc-Siglec15em1(hSIGLEC15)Smoc

SMOC番号

NM-HU-190037

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
SIGLEC15

Synonyms

Cd33l3; EG620235; SIGLEC-I

NCBI ID

620235

MGI ID

3646642

Ensembl ID

ENSMUSG00000091055

Pubmed

SIGLEC15

Human Ortholog

SIGLEC15

説明

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene.
応用分野：Immunotherapy,cancer research,drug screening

表現型データ

SIGLEC15-HU-1.png

SIGLEC15-HU-2.png

Fig1. In vivo validation of humanized SIGLEC15 mice. Humanized SIGLEC15 mice were inoculated with MC38 colon cancer cells, and were randomly assigned into different groups  when the tumors grew to a volume of 100 mm3. Human-specifc, SIGLEC15 antibody ( 5G12-hIgG1 ) was given twice a week (BIW) for two weeks (In collaboration with Crownbio).  

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