hLILRB4

系統名

C57BL/6Smoc-Lilrb4aem1(hLILRB4 )Smoc

SMOC番号

NM-HU-210024

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol

説明

The endogenous mice Lilrb4a gene was completely or partially replaced by human LILRB4 gene via CRISPR/Cas9 mediated recombination.
応用分野:inmmue therapy;drug screening

表現型データ

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Fig1. Strain specific hLILRB4 expression analysis in heterozygous hLILRB4 mice by flow cytometry. Bone marrow derived Myeloid cells, Macrophages, DC, T cells and B cells were collected and analyzed by flow cytometry with species- specific anti-hLILRB4 antibody. hLILRB4 was expressed in Myeloid cells including Macrophages and DC of heterozygous hLILRB4 mice, and not expressed in T and B cells.

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Fig2. Strain specific hLILRB4 expression analysis in heterozygous hLILRB4 mice by flow cytometry. Spleen derived Myeloid cells, Macrophages, DC, T cells and B cells were collected and analyzed by flow cytometry with species- specific anti-hLILRB4 antibody. hLILRB4 was expressed in Myeloid cells including Macrophages and DC of heterozygous hLILRB4 mice, and detectable in a small proportion of T and B cells.


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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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