hANGPTL3(4)

系統名

C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc

SMOC番号

NM-HU-210036

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Angptl3

Synonyms

hypl

NCBI ID

30924

MGI ID

1353627

Ensembl ID

ENSMUSG00000028553

Pubmed

Angptl3

Human Ortholog

ANGPTL3

説明

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.
応用分野：inmmue therapy；drug screening

表現型データ

image.png

Fig1. Detection of ANGPTL3 expression in liver by RT-PCR. Wild type: only one band at 187 bp with primers F1/R1(mAngptl3); Homozygous: only one band at 138 bp with primers F2/R2(hANGPTL3); Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Detection of hANGPTL3 and mANGPTL3 expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

Note. The hom hANGPTL3 mice was 12 weeks old, female.

image.png

Fig3. Detection of hANGPTL3 expression in serum in homozygous hANGPTL3 mice by ELISA. 

Abbr. HO, homozygous

image.png

Fig4. Monitoring of serum blood lipids levels in male hANGPTL3 mice (n=3). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig5. Monitoring of serum blood lipids levels in female hANGPTL3 mice (n=2). 

Abbr. HO, homozygous; WT, wild type.


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