NVG-hIL15
系統名
NOD.Cg-PrkdcscidIl2rgem1SmocIl15em1(hIL15)Smoc
SMOC番号
GM-NVG-210001
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Il15
説明
The endogenous mice Il15 gene was replaced by human IL15 gene.
表現型データ
Human IL15 expression analysis
Fig 1. Human IL15 expression analysis in homozygous NVG-hIL15 mice by ELISA.
Fig 2. Humanized immune reconstitution levels and body weight growth curves in huPBMC-NVG-hIL15 mice.
Fig 3. Humanized immune reconstitution levels and body weight growth curves in huPBNK-NVG-hIL15 mice.
Fig 4. Efficacy evaluation of CD20-targeting antibody using Raji huPBNK model.
Fig 5. Functional protein detection in NK cells in the presence of anti-hCD20 antibody drug using Raji huPBNK model.
Fig 6. ADCC efficacy research in vitro using huPBNK model.
Fig 7. Body weight growth curves in γδT-NVG-hIL15 mice.
Fig 8. Survial rates in γδT-NVG-hIL15 mice.
Fig 9. Humanized immune reconstitution levels in γδT-NVG-hIL15 mice.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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