hCD38(2)

系統名

C57BL/6Smoc-Cd38em2(CD38)Smoc

SMOC番号

NM-HU-190059

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CD38

Synonyms

I-19; ADPRC 1; Cd38-rs1

NCBI ID

12494

MGI ID

107474

Ensembl ID

ENSMUSG00000029084

Pubmed

CD38

Human Ortholog

CD38

説明

The endogenous mouse Cd38 gene was replaced by human CD38 gene. While hCD38 mice(Stock No.NM-HU-00113）have been pulled from shelves for some reasons.
応用分野：Immunotherapy,cancer research,drug screening

表現型データ

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Fig1. hCD38 is highly expressed on both B cells and T cells in human PBMC.

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Fig2. m/hCD38 is highly expressed on blood and spleen-derived B cells in hCD38 knockin mice.

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Fig3. m/hCD38 can be detected on blood-derived T cells in hCD38 knockin mice.

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Fig4. m/hCD38 can be detected on spleen-derived T cells in hCD38 knockin mice.

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Fig5. In vivo anti-tumor effect of Daratumumab in hCD38 knockin mice. Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab , a drug targeting human CD38, showed a very significant anti-tumor effect , demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.（ In cooperation with Crownbio）

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Fig6. Binding assay of Daratumumab to hCD38-derived B cells.（ In cooperation with Crownbio）

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Fig7. Binding assay of Daratumumab to hCD38-derived T cells.（ In cooperation with Crownbio）

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