hCD38(2)
系統名
C57BL/6Smoc-Cd38em2(CD38)Smoc
SMOC番号
NM-HU-190059
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
CD38
説明
表現型データ
Fig1. hCD38 is highly expressed on both B cells and T cells in human PBMC.
Fig2. m/hCD38 is highly expressed on blood and spleen-derived B cells in hCD38 knockin mice.
Fig3. m/hCD38 can be detected on blood-derived T cells in hCD38 knockin mice.
Fig4. m/hCD38 can be detected on spleen-derived T cells in hCD38 knockin mice.
Fig5. In vivo anti-tumor effect of Daratumumab in hCD38 knockin mice. Homozygous humanized CD38 mice were inoculated with E.G7-OVA T lymphoma cells. The results showed: Daratumumab , a drug targeting human CD38, showed a very significant anti-tumor effect , demonstrating that the humanized CD38 mouse model is a good in vivo model for validating the efficacy of antibodies targeting human CD38.（ In cooperation with Crownbio）
Fig6. Binding assay of Daratumumab to hCD38-derived B cells.（ In cooperation with Crownbio）
Fig7. Binding assay of Daratumumab to hCD38-derived T cells.（ In cooperation with Crownbio）
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