hSIGLEC10
系統名
C57BL/6Smoc-Siglecgtm1(hSIGLEC10)/Smoc
SMOC番号
NM-HU-2000061
維持形態
Embryo cryopreservation
遺伝子の概要
Gene Symbol
Siglecg
説明
表現型データ
Fig.1 Strain specific analysis of SIGLEC10 gene expression in WT and hSIGLEC10 mice by RT-PCR.
Mouse Siglecg mRNA was detectable in splenocytes of wild-type mice( P1/2 : 812bp). Human SIGLEC10 mRNA was detectable only in homozygous hSIGLEC10 mice (P3/2 : 394bp) , but not in the WT.
M：100bp Plus DNA ladder from Transgen (BM311)
Fig.2 Strain specific SIGLEC10 expression analysis in the CD19+ PBMC or splenocytes of homozygous hSIGLEC10 mice by FACS.
anti-mouse Siglec-G：BD Pharmingen™,563336；
anti-human Siglec-10：Biolegend，347603.
Fig.3 In vivo efficacy study in SIGLEC10 humanized mice grafted with MC38-hCD24 tumor model. CD24 mAb1 and CD24 mAb2 can inhibit the growth of MC38-hCD24 xenografts(A), and have no significant effect on the body weight of hSIGLEC10 mice (B).
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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