hIL10

系統名

C57BL/6Smoc-Il10tm4(hIL10)/Smoc

SMOC番号

NM-HU-2000063

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Il10

Synonyms

CSIF; Il-10

NCBI ID

16153

MGI ID

96537

Ensembl ID

ENSMUSG00000016529

Pubmed

Il10

Human Ortholog

IL10

説明

The endogenous mouse Il10 gene was replaced by human IL10 gene.
応用分野：Cytokine humanization model；drug screening

表現型データ

image.png

Fig1. Detection of IL10 expression in bladder by RT-PCR. 

Wild type: only one band at 362 bp with primers F1/R1(mIl10);

Homozygous: only one band at 196 bp with primers F2/R2(hIL10).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig2. Detection of human and mouse IL10 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL10 and C57BL/6 mice were i.p. injected with LPS for 2h.



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