hICOS

系統名

C57BL/6Smoc-Icosem1(hICOS)Smoc

SMOC番号

NM-HU-00052

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
ICOS

Synonyms

AILIM; CCLP; CRP-1; H4; Ly115

NCBI ID

54167

MGI ID

1858745

Ensembl ID

ENSMUSG00000026009

Pubmed

ICOS

Human Ortholog

ICOS

説明

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(2)(Stock No.NM-HU-190030) mice function similarly to hICOS mice,for more detailed information please contact our technical advisor.
応用分野：Immunotherapy,cancer research,drug screening

表現型データ

  • Data from flow cytometry (FACS) analysis of humanized ICOS mice

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Figure1. Expression of ICOS in the activated spleen lymphocytes of humanized ICOS mice is detected by FACS. The spleen lymphocytes of heterozygous humanized ICOS mice were stimulated by anti-CD3 and anti-CD28 for 48 h, and then harvested for staining. Along with a group undergoing no stimulation, the expression of humanized ICOS was detected by FACS after antibody staining. The results showed that the active expression of humanized ICOS can be detected in both activated CD4+ and CD8+ T lymphocytes collected from heterozygous humanized ICOS mice.

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