hPCSK9
系統名
C57BL/6Smoc-Pcsk9em2(hPCSK9)/Smoc
SMOC番号
NM-HU-00075
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Pcsk9
説明
表現型データ
Fig1 Expression of PCSK9 in the serum of humanized PCSK9 homozygous mice is detected by Elisa. a The expression of human PCSK9 can be detected in the serum collected from homozygous mice . B The expression of mouse PCSK9 can not be detected in the serum collected from homozygous mice .
Fig2 Impact of evolocumab treatment on CHOL and LDL-C levels in humanized PCSK9 homozygous mice. A single intravenous injection of evolocumab reduced CHOL(a) and LDL-C(b) in humanized PCSK9 homozygous mice after 16 weeks of high-fat diet feeding. Average + SD; n = 6 to 7 mice per condition; *p<0.05, **p<0.01; (Student’s t test).
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
詳細Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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