hOX40/hOX40L(2)

系統名

C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Tnfsf4em2(hTNFSF4)/Smoc

SMOC番号

NM-HU-200263

維持形態

Embryo cryopreservation

PDFを取得

遺伝子の概要

Gene Symbol

Synonyms

Ath1， gp34， Ath-1， Ox40l， TXGP1， CD134L， OX-40L， Tnlg2b， Txgp1l，Ox40， ACT35， CD134， Ly-70， Txgp1， TXGP1L

NCBI ID

22164，22163

MGI ID

104511，104512

Ensembl ID

ENSMUSG00000026700，ENSMUSG00000029075

Pubmed

Human Ortholog

TNFSF4，TNFRSF4

説明

hTNFSF4（NM-HU-200005）was crossed with hOX40（NM-HU-00041）to generate hOX40/hOX40L(2) mice

表現型データ

image.png

Fig1. OX40 expression on CD4+ T cells in spleen in hOX40 KI mice.

image.png

Fig2. OX40 expression on Treg cells in spleen in hOX40 KI mice. 

image.png

Fig3. Detection of hOX40L expression on stimulated APCs in hOX40/hOX40L dKI mice.image.png

Fig4. OX40 antibody showed dose-dependent anti-tumor activity in human OX40 knock-in mice bearing MC38 tumors.(The OX40 antibody was obtained from Innoventbio)

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細