hPD-1/hCTLA-4(BALB/c)

系統名

BALB/cAnSmoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc

SMOC番号

NM-HU-200277

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
CTLA4

Synonyms

Cd152; Ly-56; Ctla-4

NCBI ID

12477

MGI ID

88556

Ensembl ID

ENSMUSG00000026011

Pubmed

CTLA4

Human Ortholog

CTLA4

Gene Symbol
Pdcd1

Synonyms

PD-1; Pdc1; Ly101

NCBI ID

18566

MGI ID

104879

Ensembl ID

ENSMUSG00000026285

Pubmed

Pdcd1

Human Ortholog

PDCD1

説明

hPD-1(NM-HU-190079) was crossed with hCTLA4(2)(NM-HU-190078)to generate hPD-1/hCTLA4 mice

表現型データ

1.png

Fig 1.In vivo efficacy study in PD1 & CTLA4 humanized mice. Keytruda, Opdico or Yervoy can inhibit the growth of CT26-hCD274 xenografts. The above data indicated that the hPD1/hCTLA4 humanized mouse is an effective model for antineoplastic drug screening.

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