hF11

系統名

C57BL/6Smoc-F11em1(hF11)/Smoc

SMOC番号

NM-HU-210015

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
F11

説明

The endogenous mice F11 gene was replaced by human F11 gene
応用分野:drug screening

表現型データ

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Fig1. Detection of F11 expression in liver by RT-PCR. 

Wild type: only one band at 364 bp with primers F1/R1(mF11);Homozygous: only one band at 364 bp with primers F2/R2(hF11); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig 2. Detection of hF11 expression in plasma by ELISA (RayBiotech, ELH-CoagFXI-1). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig3. Detection of hF11 expression in plasma by ELISA (Abcam, ab108834). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig4. Prothrombinogen time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) in hF11 mice. A. 8-10 weeks of age; B. 10-12 weeks of age.


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