M-SRG

系統名

SD-Rag2em1SmocIl2rgem1Smoc

SMOC番号

NR-KO-210360

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol

Synonyms

Rag-2;gc; p64; [g]c; CD132; gamma©

NCBI ID

295953

RGD ID

Ensembl ID

ENSRNOG00000004623

Pubmed

説明

Exon 2-7of IL2rg gene in Rag2-KO(SD) rat were deleted to generate Rag2 and IL2rg knockout rat.

表現型データ

image.png

Fig1. Complete deletion of T, B and NK cells of M-SRG rats. Spleen and peripheral blood cells from SD and M-SRG rats were collected to analyze their compositions of T, B and NK cells by FACS.

image.png

Fig2. Subcutaneous xenograft tumor growth of HT29 cells in M-SRG rats.  Human colorectal adenocarcinoma cell line HT-29 (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change.

image.pngFig3. Subcutaneous xenograft tumor growth of PC-3 cells in M-SRG rats. Human prostatic adenocarcinoma cell line PC-3 (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change.

image.png

Fig4. Subcutaneous xenograft tumor growth of LNCaP clone FGC cells in M-SRG rats. Human metastatic prostate carcinoma cell line LNCaP clone FGC (2x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

image.png

Fig5. Subcutaneous xenograft tumor growth of A2780 cells in M-SRG rats.  Human ovarian cancer cell line HT-29 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

image.png

Fig6. Subcutaneous xenograft tumor growth of MV4-11 cells in M-SRG rats. Human monocytic leukemia cell line MV4-11 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A)Tumor volume. (B) Body weight change. 

image.png

Fig7. Subcutaneous xenograft tumor growth of OCI-AML-3 cells in M-SRG rats.  Human acute myeloid leukemia cell line OCI-AML-3 (1x107) were mixed with Matrigel and inoculated subcutaneously into M-SRG rats (n=6). (A) Tumor volume. (B) Body weight change.

image.png

Fig8. Blood Routine Tests in M-SRG rats.  

image.png

Fig9. Blood biochemistry in M-SRG rats. 


あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細