Cd8a-IRES-DTRGFP
系統名
C57BL/6Smoc-Cd8aem2(IRES-DTREGFP)Smoc
SMOC番号
NM-KI-190045
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Cd8a
説明
表現型データ
EGFP expression
Fig1. Validation EGFP expression in PBMC by FACS.(Cooperation with CrownBio)
Validation data of DTR function
Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. After the tumors grew to 100 mm3, the CD8a-IRES-DTRGFP mice were injected with Diphtheria toxin.
Fig2. The growth of MC38 tumors in Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice. (Cooperation with CrownBio)
Fig3. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. (Cooperation with CrownBio)
Fig4. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. Nearly complete depletion was achieved only after 1 dose administration of DT and the depletion effect lasted to day 14.(Cooperation with CrownBio)
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