Bmpr2-Flox

系統名

C57BL/6Smoc-Bmpr2em1(flox)Smoc

SMOC番号

NM-CKO-2100061

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Bmpr2

Synonyms

BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; AL117858; AW546137; BB189135; 2610024H22Rik

NCBI ID

12168

MGI ID

1095407

Ensembl ID

ENSMUSG00000067336

Pubmed

Bmpr2

Human Ortholog

BMPR2

説明

These mice carry loxP sites flanking exon 4-5 of Bmpr2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmpr2 gene.

病気の予測

Primary Pulmonary Hypertension

表現型

MGI:5430750
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Acvrl1-cre mice.

参考文献

Hong KH, Lee YJ, Lee E, Park SO, Han C, Beppu H, Li E, Raizada MK, Bloch KD, Oh SP, Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation. 2008 Aug 12;118(7):722-30

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