Ube3a-KO

系統名

C57BL/6Smoc-Ube3aem1Smoc

SMOC番号

NM-KO-200599

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Ube3a

Synonyms

Hpve6a， 4732496B02， 5830462N02Rik， A130086L21Rik

NCBI ID

22215

MGI ID

105098

Ensembl ID

ENSMUSG00000025326

Pubmed

Ube3a

Human Ortholog

UBE3A

説明

Exon 5 of Ube3a gene was deleted to generate Ube3a knockout mice.
応用分野：Diseases associated with UBE3A include Angelman Syndrome and Angelman Syndrome Due To A Point Mutation.

病気の予測

Angelman Syndrome

表現型

MGI:3694359

参考文献

Jiang YH, Armstrong D, Albrecht U, Atkins CM, Noebels JL, Eichele G , Sweatt JD , Beaudet AL, Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. Neuron. 1998 Oct;21(4):799-811

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