Tfam-Flox

系統名

C57BL/6Smoc-Tfamtm1(flox)Smoc

SMOC番号

NM-CKO-200173

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Tfam

Synonyms

Hmgts; mtTFA; tsHMG; AI661103

NCBI ID

21780

MGI ID

107810

Ensembl ID

ENSMUSG00000003923

Pubmed

Tfam

Human Ortholog

TFAM

説明

These mice carry loxP sites flanking exon 10-13 of Tfam gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tfam gene.
応用分野：Activated PKN1 stimulates the transcription of AR (androgen receptor) regulatory genes KLK2 and KLK3 and related research on mitochondrial gene expression

病気の予測

Parkinson's Disease

表現型

MGI:3702932
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a3-cre mice.

参考文献

Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG, Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30

Kearns-Sayre Syndrome

表現型

MGI:2177634
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ckmm-cre mice.

参考文献

Wang J, Wilhelmsson H, Graff C, Li H, Oldfors A, Rustin P, Bruning JC, Kahn CR, Clayton DA, Barsh GS, Thoren P, Larsson NG, Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet. 1999 Jan;21(1):133-7

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