Slc34a1-KO

系統名

C57BL/6Smoc-Slc34a1em1Smoc

SMOC番号

NM-KO-200642

維持形態

Embryo cryopreservation

PDFを取得

遺伝子の概要

Gene Symbol
Slc34a1

Synonyms

Npt2， Npt2a， Slc17a2， NaPi-IIa

NCBI ID

20505

MGI ID

1345284

Ensembl ID

ENSMUSG00000021490

Pubmed

Slc34a1

Human Ortholog

SLC34A1

説明

Exon 3-6 of Slc34a1 gene was deleted to generate Slc34a1 knockout mice.
応用分野：Research on mineral absorption and synthesis of parathyroid hormone

病気の予測

Hereditary Hypophosphatemic Rickets With Hypercalciuria

表現型

MGI:4359221
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc34A3-KO(NM-KO-2105936) mice.

参考文献

Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K, Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8

hereditary hypophosphatemic rickets with hypercalciuria

表現型

MGI:3029314

参考文献

Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS, Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5372-7

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

詳細