Sox10-KO

系統名

C57BL/6Smoc-Sox10em1Smoc

SMOC番号

NM-KO-200645

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Sox10

Synonyms

gt， Dom， Sox21

NCBI ID

20665

MGI ID

98358

Ensembl ID

ENSMUSG00000033006

Pubmed

Sox10

Human Ortholog

SOX10

説明

Exon 4-5 of Sox10 gene was deleted to generate Sox10 knockout mice.
応用分野：Research on ERK signal transduction, melanocyte development and pigmentation

病気の予測

Kallmann Syndrome

表現型

MGI:3039429

参考文献

Pingault V, Bodereau V, Baral V, Marcos S, Watanabe Y, Chaoui A, Fouveaut C, Leroy C, Verier-Mine O, Francannet C, Dupin-Deguine D, Archambeaud F, Kurtz FJ, Young J, Bertherat J, Marlin S, Goossens M, Hardelin JP, Dode C, Bondurand N, Loss-of-function mutations in SOX10 cause Kallmann syndrome with deafness. Am J Hum Genet. 2013 May 2;92(5):707-24

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