Lrat-2A-Cre

系統名

C57BL/6JSmo-Lratem1(2A-Cre)Smoc

SMOC番号

NM-KI-190097

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol
Lrat

説明

A 2A-Cre expression cassette was knocked into the Lrat gene stop codon site.
応用分野:Cre recombinase tool

表現型データ

lrat-1.png

Fig1. Expression Pattern of tdTomato in LratCre/+ ; Rosa26tdTomato/+ mice.

Cre mediated recombination in  liver nonparenchymal cells of LratCre/+ ; Rosa26tdTomato/+ mice. This strain represents an effective tool for generating liver nonparenchymal cells specific targeted mutants.

lrat-2.png

Fig2. Validation of  tdTomato  expression  by fluorescence assay.

The  liver nonparenchymal cells of Lrat-Cre mice were detected by fluorescence.

image.png

Fig. 3 Detection of tdTomato(red) in various tissues of LratCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, liver, lung, stomach, uterus, colon, intestine, muscle and spleen. Tdtomato can not be detected in the retina, brown fat, submandibular gland or thymus. (For more detailed information please contact our technical advisor.)



出版物 1piece

1. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
Published year:2022-08-02 References:Cell Metabolism

展开

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細

Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

詳細

Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

詳細