hIL1RL1

系統名

C57BL/6Smoc-Il1rl1tm4(hIL1RL1)/Smoc

SMOC番号

NM-HU-2000067

維持形態

Sperm cryopreservation

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遺伝子の概要

Gene Symbol
Il1rl1

Synonyms

T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1

NCBI ID

17082

MGI ID

98427

Ensembl ID

ENSMUSG00000026069

Pubmed

Il1rl1

Human Ortholog

IL1RL1

説明

The endogenous mouse Il1rl1 gene was replaced by human IL1RL1 gene.

応用分野：Cytokine humanization model；drug screening

表現型データ

image.png

Fig1. Detection of IL1RL1 expression in large intestine by RT-PCR in hIL1RL1 mice. 

Wild type: only one band at 296 bp with primers F1/R1(mIl1rl1);

Homoygous: only one band at 367 bp with primers F2/R2(hIL1RL1); 

Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Expression of hIL1RL1 on CD4+ T cells in spleen in hIL1RL1/hIL4/hIL4R mice (NM-HU-232112), which were generated by crossing hIL4/hIL4R (NM-HU-2000106) with hIL1RL1 (NM-HU-2000067).

image.png

Fig3. Expression of hIL1RL1 on mast cells in bone marrow in hIL1RL1/hIL4/hIL4R mice (NM-HU-232112), which were generated by crossing hIL4/hIL4R (NM-HU-2000106) with hIL1RL1 (NM-HU-2000067).

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