hFCRN

系統名

C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc

SMOC番号

NM-HU-00109

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Fcgrt

Synonyms

FcRn

NCBI ID

14132

MGI ID

103017

Ensembl ID

ENSMUSG00000003420

Pubmed

Fcgrt

Human Ortholog

FCGRT

説明

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.
応用分野：cancer research,Immunotherapy,drug screening

表現型データ

image.png

Fig1.The expression of mouse FCGRT and human FCGRT in liver was confirmed by western blotting.（Data is sourced from collaborator.）

image.png

Fig2. PK validation of human antibody (ustekinumab and briakinumab) in FCGRT humanized Mice.（Data is sourced from collaborator.）

出版物

Self-assembly of X-shaped antibody to combine the activity of IgG and IgA for enhanced tumor killing
References：Theranostics

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