hIL23A

系統名

C57BL/6Smoc-Il23aem3(hIL23A)Smoc

SMOC番号

NM-HU-18030

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Il23a

説明

The endogenous mouse Il23a gene was replaced by humanIL23A gene .
応用分野:Immunotherapy,Cancer research,Drug screening

表現型データ

image.png

Fig1. Detection of hIL23 and mIL23 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL23A/hIL12B and C57BL/6 mice were i.p. injected with LPS.


image.png

Fig2. In vivo efficacy evaluation of anti-IL-23 in imiquimod (IMQ)-induced psoriasis model in hIL23A mice (In collaboration with the third party).


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