hHLA-A2.22

系統名

C57BL/6Smoc-H2-D1em1(hHLA-A2)Smoc

SMOC番号

NM-HU-204988

維持形態

Repository Live

PDFを取得

遺伝子の概要

Gene Symbol
H2-D1

Synonyms

H-2D; H2-D; H2-K1

NCBI ID

14964

MGI ID

95896

Ensembl ID

ENSMUSG00000073411

Pubmed

H2-D1

Human Ortholog

HLA-A;HLA-B;HLA-C

説明

The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene.

表現型データ

image.png

Fig1. Detection of HLA-A2 expression in spleen and intestine by RT-PCR. Wild type: only one band at 400 bp with primers F1/R1(mH2-D1);Heterozygous: one band at 400 bp with primers F1/R1(mH2-D1) and one band at 664 bp with primers F2/R2(hHLA-A2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Expression of hHLA-A2 in blood, spleen, bone marrow and Liver in HLA-A2 KI mice. 

image.png

Fig3. Immunophenotyping in HLA-A2 KI mice.

image.png

Fig4. Immunophenotyping in Blood in HLA-A2 KI mice.

image.png

Fig5. Immunophenotyping in Spleen in HLA-A2 KI mice.

image.png

Fig6. Immunophenotyping in Bone Marrow in HLA-A2 KI mice.

あなたも好きかも

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

詳細
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

詳細