hSIGLEC8(2)

系統名

C57BL/6Smoc-Siglecfem1(hSIGLEC8)Smoc

SMOC番号

NM-HU-210033

維持形態

Embryo cryopreservation

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遺伝子の概要

Gene Symbol
Siglecf

Synonyms

Siglec5; mSiglec-F

Chromosome

7

NCBI ID

233186

MGI ID

2681107

Ensembl ID

ENSMUSG00000039013

Pubmed

Siglecf

Human Ortholog

SIGLECF

説明

The endogenous mice Siglecf gene was replaced by human SIGLEC8 gene. While hSIGLEC8(Stock No.NM-HU-204983) mice function similarly to hSIGLEC8(2) mice,for more detailed information please contact our technical advisor.
応用分野：inmmue therapy；drug screening

表現型データ

1.png

Fig1. Strain specific SIGLEC8 expression analysis in homozygouse hSIGLEC8 mice by flow cytometry. Spleen derived eosinophils were collected and analyzed by flow cytometry with species-specific anti-hSIGLEC8 and anti-mSIGLEC-F antibody. hSIGLEC8 was detectable in hSIGLEC8 mice but not in WT mice, mSIGLEC-F was detectable in WT mice but not in hSIGLEC8 mice.

2.png

Fig2. Strain specific SIGLEC8 expression analysis in homozygouse hSIGLEC8 mice by flow cytometry. Eosinophils of PBMC were collected from WT and homozygouse hSIGLEC8 mice, and analyzed by flow cytometry with species-specific anti-hSIGLEC8 and anti-mSIGLEC-F antibody. hSIGLEC8 was detectable in a small proportion of eosinophils in hSIGLEC8 mice, and the mSIGLEC-F was not expressed.


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