hIL15RA
系統名
C57BL/6JSmo-Il15ratm1(hIL15RA)Smoc
SMOC番号
NM-HU-215070
維持形態
Repository Live
遺伝子の概要
Gene Symbol
Il15ra
説明
表現型データ
Fig.1 Detection of IL15RA expression in mammary gland and spleen by RT-PCR. Mouse Il15ra mRNA (120 bp) was detectable only in wild-type C57BL/6 mice. Human IL15RA mRNA (124 bp) was detectable only in homozygous hIL15RA knockin mice but not in wild-type mice. Mammary gland and spleen RNA was extracted from 6-week-old male wild-type C57BL/6 (WT)(n=2) and homozygous hIL15RA knockin mice (HO) (n=2), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mRNA primers.
Abbr. M, marker; HO, homozygous; WT, wild type.
Fig.2 Detection of hIL15RA expression on DC cells and Macrophage in BM of WT C57BL/6 mice and HO hIL15RA mice by FACS. hIL15RA was exclusively detectable in hIL15RA humanized mice but not in wild-type mice. hIL15RA was exclusively detectable on DC cells and Macrophage in hIL15RA humanized mice. Leukocytes were collected from wild-type C57BL/6 mice (male, 6 weeks old) and homozygous HO hIL15RA humanized mice (male, 6 weeks old),stimulated with LPS in vitro(1ug/ml), and analyzed by flow cytometry with anti-mIL15RA , anti-hIL15RA.
Abbr. HO, homozygous; WT, wild type.
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