hTP53(2)

系統名

C57BL/6Smoc-Trp53tm2(hTP53)Smoc

SMOC番号

NM-HU-225052

維持形態

Repository Live

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遺伝子の概要

Gene Symbol
Trp53

説明

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

表現型データ

image.png

Fig.1 Detection of TP53 expression in thymus by RT-PCR. 

Wild type: only one band at 229 bp with primers F1/R1(mTrp53);

Homozygous: only one band at 344 bp with primers F2/R2(hTP53).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human P53 expression in hTP53(2) knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

Note. The anti-human P53 antibody cross-reacted with mouse P53 and humanized P53. hTP53(2) and C57BL/6 mice were i.p. injected with LPS.


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